Pengaruh Suplementasi Ekstrak Ikan Gabus terhadap peningkatan kadar serum Albumin Penderita Post Stroke Iskemik

ABSTRAK

Indah Puji Handayani. NIM S.530809008. Pengaruh Suplementasi Ekstrak Ikan Gabus terhadap peningkatan kadar serum Albumin Penderita Post Stroke Iskemik. Tesis: Program Studi Ilmu Gizi Program Pascasarjana Universitas Sebelas Maret Surakarta, 2014. Pembimbing I: Prof. Dr. dr. Suroto, SpS(K). Pembimbing II: dr. Tonang Dwi Ardyanto,SpPK,PhD

Latar belakang: Suplemen Ekstrak Ikan Gabus dalam sediaan kapsul mengandung protein yang sangat tinggi dengan albumin sebagai fraksi utamanya Kadar albumin serum adalah salah satu parameter untuk status gizi dan malnutrisi, dimana aktivitasnya sebagai antioksidan juga memberikan efek neuroprotektif. Stroke merupakan salah satu penyakit utama yang menyebabkan kematian dengan prevalensi yang semakin meningkat di Indonesia. Risiko malnutrisi dan infeksi cukup tinggi pada penderita post stroke iskemik. Penelitian ini bertujuan meneliti pengaruh suplementasi ekstrak ikan gabus terhadap peningkatan kadar albumin serum pada penderita post stroke iskemik sebagai salah satu upaya meningkatkan status gizi dan menurunkan risiko malnutrisi pada penderita post stroke Iskemik.

Subjek dan metode: Penelitian ini menggunakan jenis penelitian kuantitatif dengan rancangan eksperimental (pre dan pos tes). Sebanyak 30 pasien post stroke iskemik yang telah menjalani perawatan di unit stroke RSUD Dr. Moewardi Surakarta, dipilih dengan kriteria inklusi dan ekslusi sebagai sampel. Sampel dibagi menjadi 2 kelompok: kontrol (terapi standar stroke) dan perlakuan (EIG + terapi standar stroke). Intervensi pada kelompok perlakuan diberikan selama 21 hari dengan dosis 3x 1000mg EIG (2 kapsul). Kadar serum albumin (mg/dl) sebelum, minggu ke- 2, minggu ke- 3 diukur di Laboratorium Prodia Surakarta. Peningkatan rata-rata kadar serum albumin sebelum dan sesudah intervensi dibandingkan dengan Independent T test.

Hasil: Hasil analisis Independent T test menunjukkan peningkatan kadar serum albumin (mg/dl) yang lebih besar pada kelompok perlakuan (EIG + terapi standar stroke iskemik) dibandingkan kelompok kontrol (terapi standar stroke) yang secara statistik tidak signifikan, baik pada minggu ke- 2 (p= 0.199 ) dan minggu ke- 3 (p= 0.183 ).

Kesimpulan: pemberian suplementasi Ekstak Ikan Gabus (EIG) meningkatkan kadar serum albumin yang secara statistic tidak signifikan.

Kata kunci: suplemen EIG, serum albumin, post stroke iskemik

ABSTRACT

Indah Puji Handayani. NIM S.530809008. The Influence of Snakehead Fish Extract Supplementation Against Elevated Level of Albumin Serum After Ischemic stroke. Thesis: Study Program of Clinical Nutrition, Postgraduate Program of Sebelas Maret University Surakarta, 2014. First Consultant: Prof. Dr. dr. Suroto, SpS (K). Second Consultant: dr.Tonang Dwi Ardyanto, SpPK, PhD.

Objective: the supplementation of snakehead fish extract in capsules package contains a very high level of protein of which albumin is the main fraction. Albumin serum level is one of the parameters for nutrition status and malnutrition. The activities of albumin as antioxidant also provides neuroprotective effect. In aside, stroke is one of the major diseases that cause the death with increasing prevalence in Indonesia. The risk of malnutrition and infection moderately high on patients with post ischemic stroke. This research was aimed to examine the effects of snakehead fish extract supplementation on the evelation of albumin serum levels in post ischemic stroke patient. This is an effort to improve nutritional status and to reduce the risk of malnutrition in post ischemic stroke patient.

Subject and method: This was a quantitative research with experimental design (pre and post test). A total of 30 post ischemic stroke patients treated in stroke unit at Dr. Moewardi Hospital Surakarta. Subjects were selected with inclusion and exclusion criterias. The subjects were divided into 2 groups: control group (standard stroke therapy) and treated group (Snakehead Fish Extract + standard therapy of stroke). On the 21st day, a dose of 3x 1000 mg Snakehead Fish Extract (2 capsules) was administered for subject in treated group. Baseline, on the 2nd week and 3rd week of albumin serum levels (mg/dl) were measured in Prodia Laboratory Surakarta. The increase of albumin serum levels before and after the intervention were compared and analyzed with the Independent T test.

Results: The results showed differences in elevation of albumin serum levels (mg / dl) in the treated group (Snakehead Fish Extract + standard therapy for ischemic stroke) than the control group (standard therapy of stroke). The differences were not statistically significant, either on the 2nd week (p=0.199 ) and the 3rd week (p=0.183).

Conclusion: Snakehead Fish Extracts supplementation (EIG) could increase the levels of albumin serum but the difference is statistically insignificant.

Keywords: EIG supplements, albumin serum, post ischemic stroke